Advanced Delivery Systems
ADVANCED LIPID SCIENCE - EXCEPTIONAL DELIVERY SYSTEMS
Nutrasal is not your average Dietary Supplement Company.
Nutrasal is an industry leader in the use of pharmaceutical grade phospholipids. LiverFlo utilizes pharmaceutical grade PPC liposomes to increase absorption and bioavailability. The combination of liposomes and delayed release dual capsule technology make LiverFlo the most advanced and thoughtful liver product available today. LiverFlo can be considered a true breakthrough in hepatic protection and function.
Phospholipids become increasingly important as formulation excipients and as active ingredients. Nutrasal uses advanced and proprietary phospholipid methods as well as some commonly used phospholipid preparations. Phospholipid applications cover a wide spectrum within oral nutrient formulations to improve bio-availability and disposition of orally administered ingredients.
Advantages of phospholipid formulations not only comprise enhanced bioavailability of ingredients with low aqueous solubility or low membrane penetration potential, but also improvement or alteration of uptake and release of nutrients, protection of sensitive active agents from degradation in the gastrointestinal tract, reduction of gastrointestinal side effects, and even masking of bitter taste of orally applied actives
Technological strategies to achieve these effects are highly diverse and offer various possibilities of liquid, semi-liquid and solid lipid based formulations for oral and topical delivery optimization.
Phospholipids offer a number of opportunities to formulate dietary ingredients that exhibit poor water solubility or to increase the absorption and bio-availability of water soluble ingredients by increasing absorption in the mouth and along the food canal.
Liposomes are aqueous compartments enclosed by lipid bilayer membranes.
Mixed micelles are micelles comprising at least two different molecular species. Detergent-lipid mixed micelles represent disk-like structures. These micelles resemble small fragments of lipid bilayer with detergent molecules shielding the unfavorable exposure of hydrophobic parts of lipid molecules against water at their edges.
A suspension of small droplets of one liquid in a second liquid with which the former is not mixable is an emulsion. Phospholipids
can form oil-in-water as well as water-in-oil emulsions.
Micro- and nanoemulsions are based on lipids in fluid state at room temperature. They are usually prepared by high pressure
homogenization leading to droplet sizes in the range of 50-500 nm.
Self-emulsifying Nutrient Delivery Systems (SENDS)
SENDS are mixtures of oil and surfactants, ideally isotropic, sometimes including co-solvent, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal tract.
Solid Lipid Nanoparticles (SLN or SLP)
SLNs are based on "melt-emulsified" lipids, which are solid at room temperature. Particle sizes are between 40-60 nm and absorption is increased 10 fold in many cases.
A suspension consists of a liquid and a homogeneously dispersed fine-sized solid.
A phospholipid-nutrient complex is formed by interaction of the phospholipid with a functional ingredient or group of ingredients.